Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC039
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-10-05 11:58
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl Madopar a 250mg 1/2+1/4+1/2+1/4 caps Madopar HBS a 125mg jedna uvece u 22h Old patient

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 7 individuals with a value less than 0.53 were subsequently diagnosed with PD. That is, 16.67% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.53 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 5, 'TN': 6, 'TP': 37, 'FP': 24}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 31, 'TN': 26, 'TP': 11, 'FP': 4}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 34, 'TN': 28, 'TP': 8, 'FP': 2}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 9, 'TN': 5, 'TP': 33, 'FP': 25}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 18.516
timePerCircleCoV 0.245088
timePerCircleSlope 0.0167979
meanError 1.35326
tremorFreq 6.25
tremorRelPower 42.4638
tremorGyroAmpMean 0.0102317
tremorGyroAmpSlope 0.000407861
tremorGyroAmpCoV 0.395622
tremorCoordAmpMean 0.0426833
tremorCoordAmpSlope -0.00702481
tremorCoordAmpCoV 1.74181
tremorAccAmpMean 0.0720873
tremorAccAmpSlope -2.31307e-05
tremorAccAmpCoV 0.0377974
tremorPcRelVar 0.801371
tremorPcX -0.368274
tremorPcY 0.929717

Circle Segment 1

Duration 25.6 s, Accuracy Estimate 1.042 (lower is better)

Circle Segment 2

Duration 17.24 s, Accuracy Estimate 1.835 (lower is better)

Circle Segment 3

Duration 14.72 s, Accuracy Estimate 1.522 (lower is better)

Circle Segment 4

Duration 13.96 s, Accuracy Estimate 1.22 (lower is better)

Circle Segment 5

Duration 15.4 s, Accuracy Estimate 1.31 (lower is better)

Circle Segment 6

Duration 15.2 s, Accuracy Estimate 1.323 (lower is better)

Circle Segment 7

Duration 14.44 s, Accuracy Estimate 1.21 (lower is better)

Circle Segment 8

Duration 23.92 s, Accuracy Estimate 1.108 (lower is better)

Circle Segment 9

Duration 23.48 s, Accuracy Estimate 1.12 (lower is better)

Circle Segment 10

Duration 21.2 s, Accuracy Estimate 1.841 (lower is better)

Spiral

numSpirals 4
timePerSpiralMean 64.27
timePerSpiralCoV 0.195448
timePerSpiralSlope -0.104746
meanError 1.89808
tremorFreq 6.34766
tremorRelPower 35.3177
tremorGyroAmpMean 0.0137641
tremorGyroAmpSlope 0.00102536
tremorGyroAmpCoV 0.37999
tremorCoordAmpMean 0.0294997
tremorCoordAmpSlope 0.00129484
tremorCoordAmpCoV 0.339226
tremorAccAmpMean 0.046629
tremorAccAmpSlope 0.000328251
tremorAccAmpCoV 0.122524
tremorPcRelVar 0.602538
tremorPcX -0.181161
tremorPcY -0.983453

Spiral Segment 1

Duration 82.96 s, Accuracy Estimate 1.669 (lower is better)

Spiral Segment 2

Duration 56.52 s, Accuracy Estimate 1.835 (lower is better)

Spiral Segment 3

Duration 57.36 s, Accuracy Estimate 2.003 (lower is better)

Spiral Segment 4

Duration 60.24 s, Accuracy Estimate 2.085 (lower is better)

Elel

eDurationMean 0.784359
eDurationStd 0.185257
eDurationStdnorm 0.236188
eDurationMedian 0.74
eDurationQuartdelta 0.1325
eDurationQuartdeltanorm 0.179054
eDurationKurt 5.35489
eDurationTrenddiff -0.07
eDurationTrendratio 0.911392
eWidthMean 5.235
eWidthStd 1.14659
eWidthStdnorm 0.219023
eWidthMedian 5.148
eWidthQuartdelta 1.755
eWidthQuartdeltanorm 0.340909
eWidthKurt 2.73894
eWidthTrenddiff 0.117
eWidthTrendratio 1.02326
eHeightMean 8.001
eHeightStd 1.18396
eHeightStdnorm 0.147977
eHeightMedian 7.839
eHeightQuartdelta 1.4625
eHeightQuartdeltanorm 0.186567
eHeightKurt 4.49024
eHeightTrenddiff -0.702
eHeightTrendratio 0.914286
eAspectMean 0.652602
eAspectStd 0.0932571
eAspectStdnorm 0.1429
eAspectMedian 0.634921
eAspectQuartdelta 0.154978
eAspectQuartdeltanorm 0.244091
eAspectKurt 2.15247
eAspectTrenddiff 0.0546218
eAspectTrendratio 1.08997
eSlantMean 0.355525
eSlantStd 0.12364
eSlantStdnorm 0.347768
eSlantMedian 0.333333
eSlantQuartdelta 0.184247
eSlantQuartdeltanorm 0.552742
eSlantKurt 2.30319
eSlantTrenddiff 0.0658888
eRtopMean 0.942067
eRtopStd 0.0408902
eRtopStdnorm 0.0434047
eRtopMedian 0.948718
eRtopQuartdelta 0.0455728
eRtopQuartdeltanorm 0.0480362
eRtopKurt 4.31376
eRtopTrenddiff 0.0180556
eRbotMean 0.405172
eRbotStd 0.130841
eRbotStdnorm 0.322926
eRbotMedian 0.4
eRbotQuartdelta 0.166124
eRbotQuartdeltanorm 0.41531
eRbotKurt 2.26709
eRbotTrenddiff 0.0551471
eRrightMean 0.955157
eRrightStd 0.0355655
eRrightStdnorm 0.0372352
eRrightMedian 0.959459
eRrightQuartdelta 0.0600739
eRrightQuartdeltanorm 0.0626122
eRrightKurt 2.0232
eRrightTrenddiff 0.0344498
eRleftMean 0.170525
eRleftStd 0.0686954
eRleftStdnorm 0.402847
eRleftMedian 0.174603
eRleftQuartdelta 0.101327
eRleftQuartdeltanorm 0.580329
eRleftKurt 2.58457
eRleftTrenddiff 0.0259557
lDurationMean 0.899756
lDurationStd 0.14929
lDurationStdnorm 0.165923
lDurationMedian 0.855
lDurationQuartdelta 0.215
lDurationQuartdeltanorm 0.251462
lDurationKurt 2.62549
lDurationTrenddiff -0.1525
lDurationTrendratio 0.84399
lWidthMean 8.76073
lWidthStd 1.35821
lWidthStdnorm 0.155034
lWidthMedian 9.009
lWidthQuartdelta 1.55025
lWidthQuartdeltanorm 0.172078
lWidthKurt 2.95907
lWidthTrenddiff 7.10543e-15
lWidthTrendratio 1
lHeightMean 14.7192
lHeightStd 2.0587
lHeightStdnorm 0.139866
lHeightMedian 14.391
lHeightQuartdelta 2.3985
lHeightQuartdeltanorm 0.166667
lHeightKurt 4.48079
lHeightTrenddiff -1.6965
lHeightTrendratio 0.890566
lAspectMean 0.600344
lAspectStd 0.0933049
lAspectStdnorm 0.155419
lAspectMedian 0.601504
lAspectQuartdelta 0.108634
lAspectQuartdeltanorm 0.180604
lAspectKurt 3.72801
lAspectTrenddiff 0.0728938
lAspectTrendratio 1.12759
lSlantMean 0.392101
lSlantStd 0.0912589
lSlantStdnorm 0.232743
lSlantMedian 0.37037
lSlantQuartdelta 0.142662
lSlantQuartdeltanorm 0.385186
lSlantKurt 2.33878
lSlantTrenddiff 0.0913204
lRtopMean 0.95922
lRtopStd 0.0289234
lRtopStdnorm 0.030153
lRtopMedian 0.964912
lRtopQuartdelta 0.0387659
lRtopQuartdeltanorm 0.0401755
lRtopKurt 3.0421
lRtopTrenddiff 0.00382463
lRbotMean 0.307702
lRbotStd 0.093916
lRbotStdnorm 0.305217
lRbotMedian 0.309091
lRbotQuartdelta 0.119704
lRbotQuartdeltanorm 0.387277
lRbotKurt 3.14725
lRbotTrenddiff -0.0368371
lRrightMean 0.97558
lRrightStd 0.0228303
lRrightStdnorm 0.0234018
lRrightMedian 0.982609
lRrightQuartdelta 0.0269919
lRrightQuartdeltanorm 0.0274696
lRrightKurt 7.51021
lRrightTrenddiff 0.00792216
lRleftMean 0.124837
lRleftStd 0.0511717
lRleftStdnorm 0.409909
lRleftMedian 0.12
lRleftQuartdelta 0.0677161
lRleftQuartdeltanorm 0.564301
lRleftKurt 4.52315
lRleftTrenddiff -0.0169606

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

FITTS Short Modified

meanTouchScore 0.939801
sumTouchScores 20.6756
meanMovementTime 0.79619
numTouches 22
undershootPercentage 0
overshootPercentage 4.54545

FITTS Long Modified

meanTouchScore 0.872081
sumTouchScores 14.8254
meanMovementTime 1.21125
numTouches 17
undershootPercentage 5.88235
overshootPercentage 17.6471

fitts_long data not in signals file.

ZigZag

numZigzags 5
timePerZigzagMean 43.024
timePerZigzagCoV 0.135573
timePerZigzagSlope 0.068334
meanError 2.19172
tremorFreq 6.05469
tremorRelPower 41.7196
tremorGyroAmpMean 0.0167949
tremorGyroAmpSlope 0.00118491
tremorGyroAmpCoV 0.323794
tremorCoordAmpMean 0.0480763
tremorCoordAmpSlope 0.00309744
tremorCoordAmpCoV 0.954587
tremorAccAmpMean 0.0336368
tremorAccAmpSlope -0.000165085
tremorAccAmpCoV 0.226561
tremorPcRelVar 0.833635
tremorPcX 0.145611
tremorPcY 0.989342

ZigZag Segment 1

Duration 37.84 s, Accuracy Estimate 2.685 (lower is better)

ZigZag Segment 2

Duration 38.92 s, Accuracy Estimate 2.629 (lower is better)

ZigZag Segment 3

Duration 46.12 s, Accuracy Estimate 1.986 (lower is better)

ZigZag Segment 4

Duration 40.48 s, Accuracy Estimate 1.939 (lower is better)

ZigZag Segment 5

Duration 51.76 s, Accuracy Estimate 1.719 (lower is better)

ZigZag Offset

numZigzags 6
timePerZigzagMean 26.5533
timePerZigzagCoV 0.0750933
timePerZigzagSlope -0.0271583
zigzagHeightMean 51.7242
zigzagHeightCoV 0.110646
zigzagHeightSlope -0.0321342
meanError 0.0318828
tremorFreq 6.15234
tremorRelPower 40.2515
tremorGyroAmpMean 0.0182222
tremorGyroAmpSlope 0.000905672
tremorGyroAmpCoV 0.377878
tremorCoordAmpMean 0.105919
tremorCoordAmpSlope -0.000287611
tremorCoordAmpCoV 1.02449
tremorAccAmpMean 0.0686915
tremorAccAmpSlope 0.000243408
tremorAccAmpCoV 0.0685216
tremorPcRelVar 0.83501
tremorPcX -0.175523
tremorPcY -0.984475

ZigZag Offset Segment 1

Duration 28.92 s, Accuracy Estimate 0.042 (lower is better)

ZigZag Offset Segment 2

Duration 26.6 s, Accuracy Estimate 0.029 (lower is better)

ZigZag Offset Segment 3

Duration 25.56 s, Accuracy Estimate 0.033 (lower is better)

ZigZag Offset Segment 4

Duration 28.44 s, Accuracy Estimate 0.025 (lower is better)

ZigZag Offset Segment 5

Duration 26.36 s, Accuracy Estimate 0.028 (lower is better)

ZigZag Offset Segment 6

Duration 23.44 s, Accuracy Estimate 0.034 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.66}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.53}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.16466568220176647}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.5751969164804309}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.8015260902824735}